Research advances of monocytes or macrophages in neonatal necrotizing enterocolitis
毛孟佳 1田钰欣 1沈淳1
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作者信息
1. 国家儿童医学中心，复旦大学附属儿科医院小儿外科，上海 201102
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摘要
坏死性小肠结肠炎（necrotizing enterocolitis，NEC）是一种主要发生于早产儿的严重胃肠道疾病，病死率较高，但其发病机制尚未明确。作为固有免疫的一部分，单核/巨噬细胞在NEC的发生和发展中发挥重要作用。本文现就单核/巨噬细胞在NEC发病机制中的研究进展作一综述。 As a severe gastrointestinal disease, necrotizing enterocolitis (NEC) affects premature infants with a high mortality. However, its pathogenesis remains largely elusive. As components of innate immunity, monocytes or macrophages play an important role in the onset and development of NEC. This review summarized the latest researches of monocytes or macrophages in the pathogenesis of NEC.
Abstract
As a severe gastrointestinal disease, necrotizing enterocolitis (NEC) affects premature infants with a high mortality. However, its pathogenesis remains largely elusive. As components of innate immunity, monocytes or macrophages play an important role in the onset and development of NEC. This review summarized the latest researches of monocytes or macrophages in the pathogenesis of NEC.
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