Evaluations of nonthyroidal illness syndrome in children after congenital heart surgeries with car-diopulmonary bypass
Objective To explore the incidence and related risk factors of nonthyroidal illness syndrome(NTIS)and to explore the association between NTIS and postoperative clinical outcomes in children with congenital heart disease(CHD)after cardiac surgery.Methods From March 2022 to May 2022,the relevant clinical data were retrospectively reviewed for 402 CHD children undergoing operations.There were 195 boys and 207 girls with a median age of 17(5-48)months and a median weight of 10(6-15)kg.They were assigned into two groups of NTIS(n=76)and non-NTIS(n=326).The risk factors for NTIS in children with precardiac disease were evaluated by binary Logistic regression and correlation analysis was performed for independent risk factors.Results Among them,76 patients(18.9％)developed NTIS after cardiac surgery.As compared with non-NTIS group,NTIS group were more younger(12 vs 19 months,P=0.04)and had lower body weight(8.2 kg vs.10.6 kg,P=0.016).Mechanical ventilation time was significantly higher in NTIS group than that in non-NTIS group(28.5 vs 6 h,P＜0.001).ICU length of stay was significantly higher than that in non-NTIS group(10 vs 3 day,P＜0.001)and adverse complication rate longer(11％vs 1％,P＜0.001).Multivariate analysis indicated that cardiopulmonary bypass(CPB)time＞120 min is an independent risk factor for NTIS after cardiac surgery in CHD children(OE=5.36,95％CI:1.69-17.01,P=0.004).And a negative correlation exists between fT3 and CPB time(r=-0.274,P＜0.001).
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