Whether or not hepatoportoenterostomy(HPE)should be performed on all children of biliary atresia(BA)and whether HPE has some adverse effect on sequential liver transplantation(SLT)are thought-provoking.With the development of living donor liver transplantation,distinguishing BA patients benefiting from primary liver transplantation(PLT)has remained a great challenge for pediatric surgeons.Literature review was conducted with regards to long-term survival of native liver after HPE,impact of HPE on SLT and preoperative indicators for evaluating the prognosis of patients.