Objective To study the clinical characteristics and risk factors of nephrocalcinosis in preterm infants.Methods From March 2021 to August 2021,all preterm infants admitted to NICU of our hospital were retrospectively analyzed.The infants were assigned into nephrocalcinosis group and non-nephrocalcinosis group according to urinary tract ultrasound.Clinical data including gestational age,birth weight(BW),nutritional support strategy and complications were reviewed.Results A total of 40 preterm infants(＜34 weeks)were enrolled.9 cases were in the nephrocalcinosis group and 31 cases in the non-nephrocalcinosis group.The nephrocalcinosis group had lower BW[(1 167±214)g vs.(1 586±215)g],higher calcium[6.9(5.1,8.7)g vs.3.3(2.1,6.8)g]and vitamin D intake[3.2(2.5,4.2)×104U vs.1.7(1.1,3.2)×104U]during hospitalization.No significant differences existed between the two groups on the following items:blood calcium and phosphate,25-hydroxyvitamin D,feeding strategy,time to reach full enteral feeding(TFF),furosemide dosage and respiratory support duration(P＞0.05).In the nephrocalcinosis group,the median age of diagnosing nephrocalcinosis was 40.0(30.0,52.5)d after birth.5 cases showed bilateral nephrocalcinosis.5 cases in the nephrocalcinosis group received renal tubule function examination,4 cases had increased urine β2 microglobulin and 2 cases had increased urine α1 microglobulin.7 cases had elevated urine calcium in the nephrocalcinosis group.Follow-up showed that nephrocalcinosis disappeared 3-9 months after birth.Conclusions BW,total calcium and vitamin D intake are risk factors for nephrocalcinosis in preterm infants.Increased urine β2 microglobulin and calcium levels are common co-morbidities in preterm infants with nephrocalcinosis.
关键词
肾钙沉着/早产儿/高钙尿症/利尿剂/肾小管功能不成熟
Key words
Nephrocalcinosis/Preterm infants/Hypercalciuria/Diuretics/Immature renal tubular function
维普
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