小于胎龄早产儿生后早期振幅整合脑电图特征分析
Amplitude-integrated electroencephalogram characteristics of small for gestational age preterm infants
孔艳婷 1刘昱 1赵俊婕 1张国庆 1步军 1郭薇薇 1贝斐1
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心新生儿科,上海 200127
- 折叠
摘要
目的 探讨小于胎龄(small for gestational age,SGA)早产儿生后早期振幅整合脑电图(amplitude integrated electroencephalogram,aEEG)的特征.方法 选取 2021 年 5 月至 2023 年 5 月于上海儿童医学中心住院治疗,生后1周内完善aEEG的早产儿进行回顾性分析,根据出生体重分为SGA组和适于胎龄(appropriate for gestational age,AGA)组,根据校正胎龄36～40周头颅MRI/超声结果分为神经系统近期结局良好和近期结局不良,应用SPSS 26.0统计软件比较SGA组与AGA组的临床特点及aEEG Burdjalov分值.结果 SGA组50例,AGA组95例.SGA组神经系统近期结局不良发生率高于 AGA 组[26.0％(13/50)比 6.3％(6/95),P＜0.05].SGA 组 aEEG Burdjalov 总分、连续性、睡眠-觉醒周期、下边界振幅、波谱带宽得分均低于AGA组(P＜0.05).神经系统近期结局良好的早产儿中,SGA组连续性、下边界振幅得分高于AGA组(P＜0.05),两组aEEG Burdjalov总分、睡眠.觉醒周期、波谱带宽得分差异无统计学意义(P＞0.05).结论 与同胎龄AGA早产儿相比,SGA早产儿生后早期aEEG波形更不成熟.但对于神经系统近期结局良好的早产儿,SGA早产儿生后早期aEEG波形比同胎龄AGA早产儿更为连续、成熟.
Abstract
Objectives To study the characteristics of amplitude integrated electroencephalogram(aEEG)in small for gestational age(SGA)preterm infants early after birth.Methods From May 2021 to May 2023,preterm infants hospitalized and completed aEEG within 1w after birth were retrospectively studied.According to birth weight,the infants were assigned into SGA group and appropriate gestational age(AGA)group.According to head ultrasound/MRI data at 36～40 weeks of corrected gestational age,they were assigned into good and poor neurological outcome groups.SPSS 26.0 statistical software was used to compare the clinical characteristics and aEEG Burdjalov scores between SGA group and AGA group.Results A total of 145 preterm infants were enrolled,including 50 in SGA group and 95 in AGA group.The SGA group had a significantly higher incidences of severe intracranial hemorrhage/brain injury than the AGA group[26.0％(13/50)vs.6.3％(6/95),P＜0.05].Comparing with the AGA group,the SGA group had significantly lower Burdjalov score,continuity score,sleep-wake cycle score,boundary amplitude and spectral bandwidth(P＜0.05).For infants with good neurological outcome,the SGA group had significantly higher continuity score and lower boundary amplitude than the AGA group(P＜0.05),and no significant differences existed in Burdjalov score,sleep-wake cycle score and spectral bandwidth between the two groups(P＞0.05).Conclusions Early after birth,SGA preterm infants shows more immature aEEG than AGA infants of the same gestational age.However,for preterm infants with good neurological outcome,SGA infants shows more continuous and mature aEEG than AGA infants of the same GA.
关键词
小于胎龄儿/早产儿/振幅整合脑电图/神经系统结局Key words
Small for gestational age infants/Premature infants/Amplitude-integrated electroencephalogram/Neurological outcome引用本文复制引用
基金项目
上海市浦东新区卫健委课题(PW2022D-09)
上海市浦东新区科技发展基金事业单位民生科研专项(PKJ2021-42)
出版年
2024
NETL
NSTL
万方数据