组织学绒毛膜羊膜炎对早产儿支气管肺发育不良影响的Meta分析
A meta-analysis of the effects of histological chorioamnionitis on bronchopulmonary dysplasia in premature infants
张杰 1梅花 1新春 1霍梦月1
作者信息
- 1. 内蒙古医科大学附属医院新生儿科,呼和浩特 010050
- 折叠
摘要
目的 探讨孕母组织学绒毛膜羊膜炎(histological chorioamnionitis,HCA)与早产儿支气管肺发育不良(bronchopulmonary dysplasia,BPD)之间的关系.方法 计算机检索PubMed、Embase、Cochrane Library、维普、中国知网、中华医学期刊全文数据库和万方数据库自建库至2023年10月关于孕母HCA与新生儿BPD之间相关性的队列研究,采用Newcastle-Ottawa Scale量表对纳入文献进行质量评价,应用RevMan 5.4软件进行Meta分析.结果 共纳入7篇文献,1 535例早产儿,其中HCA组943例,非HCA组592例.HCA组BPD发生率显著高于非HCA组(RR=2.45,95％CI 1.74～3.44,P＜0.001),HCA组脑室内出血(RR=1.63,95％CI 1.11～2.38,P=0.01)、新生儿坏死性小肠结肠炎(RR=1.94,95％CI1.03～3.65,P=0.04)和新生儿早发败血症(RR=2.06,95％CI 1.50～2.84,P＜0.001)的发生率也高于非HCA组.结论 孕母HCA显著提高新生儿发生BPD的风险,并增加其他相关并发症的风险.
Abstract
Objective To explore the relationship between maternal histological chorioamnionitis(HCA)and bronchopulmonary dysplasia(BPD)in premature infants.Methods The cohort studies on the correlation between maternal HCA and neonatal BPD from PubMed,Embase,Cochrane Library,VIP,CNKI,Chinese Medical Journal Full-text Database and Wanfang Database were searched by until October 2023.Newcastle-Ottawa Scale was used to evaluate the quality of the included literature,and the RevMan 5.4 software was used for meta-analysis.Results A total of 7 articles were included,with 1 535 premature infants,including 943 in the HCA group and 592 in the non-HCA group.The incidence of BPD in HCA group was higher than that in non-HCA group,the difference was significant(RR=2.45,95％CI 1.74-3.44,P＜0.001),intraventricular hemorrhage(RR=1.63,95％CI 1.11-2.38,P=0.01),neonatal necrotizing enterocolitis(RR=1.94,95％CI 1.03-3.65,P=0.04)and early onset sepsis(RR=2.06,95％CI 1.50-2.84,P＜0.001)were also higher than those in the non-HCA group.Conclusions Maternal HCA significantly increases the risk of neonatal BPD and other related complications.
关键词
绒毛膜羊膜炎/组织学/早产儿/支气管肺发育不良/Meta分析Key words
Chorioamnionitis/Histological/Premature infants/Bronchopulmonary dysplasia/Meta-analysis引用本文复制引用
基金项目
内蒙古自然科学基金(2020MS08034)
出版年
2024
NETL
NSTL
万方数据