Logistic regression analysis of factors influencing peripherally inserted central catheter-related venous thrombosis in hematologic disorders
Background Peripherally inserted central catheter(PICC)is the preferred vascular access method in patients with hematologic disorders.This study examined the incidence and influential factors of PICC-related venous thrombosis(PICC-RVT)in patients with hematologic disorders.Methods Patients with hematologic disorders who underwent PICC placement at our hospital between January 2018 and December 2022 were included.General characteristics,laboratory results,and relevant PICC and medication data were collected.Baseline characteristics between the thrombotic and non-thrombotic groups were balanced using 1∶5 propensity score matching(PSM).Binary logistic regression analysis was used to investigate the factors influencing PICC-RVT development.Multivariate regression results were validated using receiver operating characteristic(ROC)curve analysis.Results In total,63 of 4345(1.45%)patients who developed PICC-RVT were recruited.After PSM balancing,63 cases were in the thrombosis group and 388 cases in the non-thrombosis group,and a total of 451 cases were analyzed.Binary logistic regression analysis showed that factors affecting the occurrence of PICC-RVT in patients with hematological disorders were diagnosis(OR=0.429,P<0.001),body mass index(BMI)(OR=0.504,P<0.05),white blood cell count(WBC)(OR=0.443,P<0.001),platelet count(OR= 1.902,P<0.05),D-dimer level(OR=1.135,P<0.05)and blood product transfusion(OR=3.348,P<0.001).The area under the ROC curve was 0.847,and the sensitivity and specificity were 0.794 and 0.753,respectively,indicating that the model was significant for predicting PICC-RVT(P<0.001).Conclusion Diagnosis.,BMI,WBC,PLT,D-D,blood product transfusion influenced the probability of PICC-RVT in patients with hematologic disorders.
万方数据
维普
