Evaluation of prognostic value for multiple trauma patients by combination of prothrombin time and fibrin degradation products
Objective To evaluate the clinical values such as plasma fibrinogen degradation products and prothrombin time to determine the prognosis of patients with multiple injuries.Methods A total of 163 patients with multiple injuries admitted to the Department of Critical Care Medicine at the 902 Hospital from September 2020 to July 2023 were selected and divided into the survival group(150 cases)and the death group(13 cases)according to their prognosis within 90 days after admission.General data and coagulation test indicators including plasma prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),thrombin time(TT),D-dimer(DD),fibrin degradation products(FDP),and platelet count(PLT)were retrospectively collected and statistically analyzed.Results Compared with the survival group,the PT[14.6(13.3～16.3)s]and PLT[121(80～178)×109/L]in the death group were significantly prolonged,and the PLT[101(50～123)×109/L]was significantly decreased(P<0.05).Compared with the survival group,the FDP[28.63(15.32～57.59)μg/mL]and D-D[6.62(2.89～18.56)μg/mL]in the death group were significantly increased(P<0.05).Logistic regression analysis showed that FDP and PT were significantly associated with the prognosis of trauma patients.ROC curve analysis showed that the AUC of FDP combined with PT for predicting trauma prognosis was 0.788,with a sensitivity and specificity of 80%and 72.5%,respectively.Conclusion Prolonged PT and elevated FDP are risk factors for poor prognosis in trauma patients,and PT combined with FDP can be used to predict the prognosis of trauma patients.
TraumaFibrin degradation productPrognosisProthrombin time
NETL
NSTL
万方数据
维普
