Analysis of genes related to the pathogenesis of chronic primary immune thrombocy-topenia
Objective We summarized and analyzed the relevant studies on the pathogenesis of CITP,in order to clarify the pathogenesis of CITP.Methods Using"chronic thrombocytopenia"and"chronic immune thrombocytopenia"as keywords,we searched the literature through CNKI and PubMed,genes involved in the pathogenesis were extracted and annotated.The possible pathogenic genes were selected for GO-BP functional enrichment and KEGG pathway analysis.Then we identified the core genes according to the degree of relevance by constructing a gene interaction network.Results A total of 33 Chinese articles and 42 English articles concerning to the pathogenesis of CITP were searched.We extracted 97 related genes,including 73 possible pathogenic genes of CITP.These functional enriched pathogenic genes were mainly involved in biological processes such as inflammation,immune response,B cell proliferation,cytokine releases,and signal transduction.KEGG analysis showed that the relevant pathways were mainly enriched in cytokine receptor interaction,helper T cell differentiation,JAK-STAT,NF-kappa B,TCR,IL-17,PD-1 checkpoint and other signaling pathways.The top 20 core genes were mainly inflammatory factors(TNF,various interleukins)and negative immune regulators(CTLA4,PD-EOB-L1).Conclusion The pathogenesis of CITP is associated with abnormal immune activation.The core pathogenic genes are associated with inflammatory factors and negative immune regulators.The biological processes and signaling pathways related to CITP mainly focused on inflammation,immune response,immune cell proliferation and differentiation.
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