The digitalization of cross-border trade motivates the development of cross-border e-commerce(CBEC).To inspire the small and medium-sized companies to participate in the innovative CBEC practice,165 CBEC comprehensive pilot zones have been established in different batches and the so-called"no-ticket exemption"policy has also been introduced.In this paper,the integrated optimization of the CBEC supply chain network design and the tax-declaring strategies are studied,and both the comprehensive experimental zones and the"no-ticket exemption"policy are taken into account.A two-stage nonlinear stochastic programming model is devel-oped,in which,uncertain demands and exchange rates are involved.To optimally solve it,the proposed model is linearized and an optimally dedicated L-shaped algo-rithm is designed.The case study shows that the"no-ticket exemption"policy can significantly decrease the tax burden of the CBEC companies,and then,attract the CBEC companies to deploy their hubs in the comprehensive pilot zones.Moreover,the introduction of the"Regional Comprehensive Economic Partnership"agreement would alleviate the difference between overseas warehouses and domestic warehouses and inspire the CBEC companies to concentrate cargo logistics to a few overseas warehouses with geographical superiority.Both of the two policies can reduce the layout cost of supply chain network of the CBEC companies.