双歧杆菌二联活菌胶囊联合盐酸氟西汀治疗老年肠易激综合征伴焦虑抑郁的效果分析
Efficacy of Bifidobacterium Biactive Capsule Combined with Fluoxetine Hydrochloride in the Treatment of Irritable Bowel Syndrome with Anxiety and Depression in the Elderly
郭红丽1
作者信息
- 1. 济南市第二精神卫生中心,山东济南 250000
- 折叠
摘要
目的 分析双歧杆菌二联活菌胶囊加盐酸氟西汀用于肠易激综合征伴焦虑抑郁老年患者的效果.方法 选取2020年1月—2022年12月济南市第二精神卫生中心收治的45例肠易激综合征伴焦虑抑郁患者,经随机数表法分成对照组(常规药物加心理治疗)23例、观察组(在对照组基础上采取双歧杆菌二联活菌胶囊加盐酸氟西汀)22例,比较两组疗效,治疗前后腹泻、腹痛、大便性状得分,焦虑及抑郁得分、不良反应出现情况.结果 观察组总有效率为95.45%,高于对照组的69.57%,差异有统计学意义(P<0.05).治疗前,两组腹泻、腹痛以及大便性状得分比较,差异无统计学意义(P>0.05);治疗后,观察组腹泻、腹痛以及大便性状得分均低于对照组,差异有统计学意义(P<0.05).治疗前,两组焦虑以及抑郁得分对比,差异无统计学意义(P>0.05);治疗后,观察组焦虑以及抑郁得分均低于对照组,差异有统计学意义(P<0.05).两组嗜睡、恶心呕吐、头痛以及乏力等不良反应发生率比较,差异无统计学意义(P>0.05).结论 双歧杆菌二联活菌胶囊加盐酸氟西汀用于肠易激综合征伴焦虑抑郁老年患者疗效理想,能改善其腹泻、腹痛以及大便形状等临床症状,减轻其焦虑抑郁情绪,安全性高.
Abstract
Objective To analyze the effect of bifidobacterium biactive capsule combined with fluoxetine hydrochlo-ride on irritable bowel syndrome with anxiety and depression in elderly patients.Methods 45 patients with irritable bowel syndrome and anxiety and depression admitted to the Second Mental Health Center of Jinan City from January 2020 to December 2022 were selected and divided into control group(conventional drugs plus psychotherapy)23 cases and observation group(bifidobacterium combined with fluoxetine hydrochloride on the basis of the control group)22 cases.The efficacy,diarrhea,abdominal pain,stool trait scores,anxiety and depression scores,and adverse reac-tions between the two groups before and after treatment were compared.Results The total effective rate of the observa-tion group 95.45%was higher than that of the control group(69.57%),and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the scores of diarrhea,abdominal pain and stool traits between the two groups(P>0.05);after treatment,the scores of diarrhea,abdominal pain and stool traits in the observation group were lower than those in the control group,and the differences were statistically signifi-cant(P<0.05).Before treatment,there was no statistically significant difference in anxiety and depression scores be-tween the two groups(P>0.05);after treatment,the scores of anxiety and depression in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statisti-cally significant difference in the incidence of adverse reactions such as drowsiness,nausea and vomiting,headache and fatigue between the two groups(P>0.05).Conclusion Bifidobacterium biactive capsule combined with fluoxetine hydrochloride has ideal efficacy in the elderly patients with irritable bowel syndrome accompanied by anxiety and de-pression,which can improve the clinical symptoms such as diarrhea,abdominal pain and stool characteristics,and re-duce their anxiety and depression.
关键词
盐酸氟西汀/双歧杆菌二联活菌胶囊/肠易激综合征/焦虑/抑郁Key words
Fluoxetine hydrochloride/Bifidobacterium biactive capsule/Irritable bowel syndrome/Anxiety/Depressed引用本文复制引用
出版年
2023
NETL
NSTL
维普
万方数据