Qiming Granule Combined with Conbercept in the Treatment of Diabetic Macular Edema and Its Effect on the Level of Vascular Growth Factor
Objective To investigate the clinical efficacy of Qiming Granule combined with Conbercept in the treat-ment of diabetic macular edema and its influence on the level of vascular growth factor.Methods A total of eighty pa-tients with diabetic macular edema who received treatment in Hongqi Hospital Affiliated to Mudanjiang Medical Col-lege from February 2022 to May 2023 were selected as the objects and randomly divided into control group and obser-vation group according to the random number table,with forty cases in each group.The control group was treated with Conbercept,and the observation group added Qiming Granule for treatment.The clinical efficacy,visual acuity level,degree of macular edema,vascular endothelial growth factor,oxidative free radical level and treatment safety of the two groups were compared and evaluated.Results The total effective rate of observation group was 92.50%(37/40),which was higher than that of control group 75.00%(30/40),and the difference was statistically significant(χ2=4.501,P=0.034).After treatment,the best corrected visual acuity in the observation group was higher than that in the control group,and the retinal thickness and electroretinogram oscillating potential in macular area were lower than those in the control group,the differences were statistically significant(all P<0.05).After treatment,the levels of vascular endo-thelial growth factor receptor 1,fibroblast growth factor receptor and transforming growth factor β1 in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).After treat-ment,the levels of malondialdehyde and 8-hydroxylated deoxyguanosine in observation group were lower than those in control group,and the levels of superoxide dismutase were higher than those in control group,the differences were sta-tistically significant(all P<0.05).The incidence of adverse reactions was 12.50%(5/40)in the observation group and 7.50%(3/40)in the control group,and there was no statistically significant difference between the two groups(P>0.05).Conclusion Qiming Granule combined with Compaercep has a good application effect in the treatment of dia-betic macular edema,which can improve the visual acuity level,reduce the thickness of macular edema,inhibit the level of vascular growth factor,improve the oxidative stress response ability of the body,and the treatment safety is good.
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