Correlation Study of Serum Brain Natriuretic Peptide and Procalcitonin Changes with NYHA Classification in Heart Failure Patients
王文静 1王文青 2刘明丽3
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作者信息
1. 玉溪市第二人民医院老年病科,云南玉溪 653100
2. 云南省红河州中医院手术室,云南红河 654300
3. 玉溪市第二人民医院检验科,云南玉溪 653100
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摘要
目的 分析血清脑钠肽、降钙素原变化与心力衰竭患者纽约心脏病协会(New York Heart Association,NYHA)分级的相关性.方法 选取2019年5月—2023年2月云南省玉溪市第二人民医院收治的97例心力衰竭患者为研究对象,所有患者都进行NYHA心功能分级后分为3组,心功能Ⅱ级57例(Ⅱ级组),心功能Ⅲ级28例(Ⅲ级组),心功能Ⅳ级12例(Ⅳ级组),检测3组血清脑钠肽、降钙素原含量并进行相关性分析.结果 随着NYHA分级的增加,患者的左室射血分数明显降低,左室舒张末期内径明显升高,差异有统计学意义(P均<0.05).随着NYHA分级的增加,患者的血清脑钠肽、降钙素原含量明显升高,差异有统计学意义(P均<0.05).Spearman分析显示NYHA分级与血清脑钠肽、降钙素原含量、左室射血分数、左室舒张末期内径存在相关性(r=0.714、0.746、-0.788、0.692,P均<0.05).结论 心力衰竭患者多伴随有血清脑钠肽、降钙素原的高表达,与患者的NYHA分级存在相关性,可作为判断患者病情的重要依据.
Abstract
Objective To analyze the correlation between the changes of serum brain natriuretic peptide and procalci-tonin and the New York Heart Association(NYHA)classification of heart failure patients.Methods A total of 97 pa-tients with heart failure who were admitted to the Yuxi Second People's Hospital,Yunnan Province from May 2019 to February 2023 were selected as the research objects.All patients were divided into 3 groups after NYHA cardiac func-tion classification,including 57 cases of cardiac function grade Ⅱ(class Ⅱ group),28 cases of cardiac function gradeⅢ(class Ⅲ group),12 cases of cardiac function grade Ⅳ(class Ⅳ group).The serum levels of brain natriuretic pep-tide and procalcitonin of three groups were detected and the correlation was analyzed.Results With the increase of NYHA classification,left ventricular ejection fraction was significantly decreased,and left ventricular end-diastolic diameter was significantly increased,and the differences were statistically significant(both P<0.05).With the increase of NYHA classification,the serum levels of brain natriuretic peptide and procalcitonin were significantly increased,and the differences were statistically significant(both P<0.05).Spearman analysis showed that NYHA classification was correlated with serum brain natriuretic peptide,procalcitonin,left ventricular ejection fraction and left ventricular end-diastolic diameter(r=0.714,0.746,-0.788,0.692,all P<0.05).Conclusion Heart failure patients are mostly ac-companied by high expression of serum brain natriuretic peptide and procalcitonin,and there is a correlation with pa-tients'NYHA classification,which can be used as an important basis for judging patients'conditions.
关键词
心力衰竭/脑钠肽/降钙素原/纽约心脏病协会心功能分级/相关性/左室舒张末期内径
Key words
Heart failure/Brain natriuretic peptide/Procalcitonin/New York Heart Association cardiac function classification/Correlation/Left ventricular end-diastolic inner diameter
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