Effect of Aspirin Combined with Clopidogrel in the Treatment of Cerebral Infarction
Objective To explore the clinical effect of aspirin combined with clopidogrel in patients with cerebral in-farction.Methods A total of seventy-six patients with cerebral infarction who received treatment in Jingjiang People's Hospital from July 2021 to December 2022 were selected as the study objects,and were divided into observation group and reference group according to random number table method,with thirty-eight patients in each group.The ref-erence group was treated with aspirin,and the observation group was treated with clopidogrel on the basis of aspirin.Serum inflammatory factors,blood flow indexes and oxidase activity indexes were compared between the two groups.Results After treatment,symptoms improved in both groups.The levels of C-reactive protein,interleukin-6,interleu-kin-8 in the observation group were(4.53±0.97)mg/L,(5.22±1.98)pg/mL and(60.28±2.78)ng/mL,respectively,which were significantly better than those in the reference group,and the difference was statistically significant(t= 15.180,7.789,22.697,all P<0.05).The plasma viscosity,platelet aggregation rate and whole blood viscosity were(1.12±0.02)mPa·s,(58.42±5.13)%and(3.01±0.56)mPa·s,respectively,which were significantly better than those of the reference group,and the difference was statistically significant(t=22.695,7.239,4.484,all P<0.05).The indexes of superoxide dismutase,malondialdehyde and hydrooxidase in the observation group were(74.56±2.95)kU/L,(3.24±1.11)nmol/mL and(26.28±5.71)IU/mL,respectively,which were better than those in the reference group,and the dif-ferences were statistically significant(t=18.287,3.131,5.746,all P<0.05).Conclusion In the treatment of cerebral in-farction,aspirin combined with clopidogrel can significantly improve the hemorheology index of patients,reduce the level of serum inflammatory factors,and promote the oxidase activity index to return to normal value,which has a sig-nificant clinical effect.
AspirinClopidogrelCerebral infarctionSerum inflammatory factorsHematologyOxidase activity index
万方数据
维普
