目的 探讨神经介入结合阿替普酶静脉溶栓治疗急性缺血性脑卒中的效果以及出血风险.方法 选取2020年1月—2023年1月连云港市赣榆区人民医院收治的106例急性缺血性脑卒中患者,以随机数表法分为对照组和观察组,各53例.对照组采取神经介入手术治疗,观察组则接受阿替普酶静脉溶栓后桥接神经介入手术治疗.对比两组血流动力学指标、神经功能缺损量表(National Institute of Health Stroke Scale,NIHSS)评分、改良Rankin量表(Modified Rankin Scale,mRS)评分及出血情况.结果 治疗后,两组血流动力学指标均有所改善,且观察组改善程度优于对照组,差异有统计学意义(P<0.05).治疗后,观察组NIHSS评分与mRS评分均低于对照组患者,差异有统计学意义(P均<0.05).观察组出血发生率为5.66%,对照组出血发生率为9.43%,两组比较差异无统计学意义(χ2=0.541,P>0.05).结论 阿替普酶静脉溶栓治疗联合神经介入治疗可明显改善急性缺血性脑卒中患者的血流动力学和神经功能缺损情况,安全性更高,治疗后出血发生率显著降低.
Study on the Efficacy and Bleeding Risk of Acute Ischemic Stroke Treated by Nerve Intervention Combined with Alteplase Intravenous Thrombolysis
Objective To investigate the effect of nerve intervention combined with alteplase intravenous thrombolysis in the treatment of acute ischemic stroke and the risk of bleeding.Methods A total of 106 patients with acute isch-emic stroke treated in Ganyu District People's Hospital of Lianyungang City from January 2020 to January 2023 were selected and divided into control group and observation group by random number table method,with 53 cases in each group.The control group received nerve interventional surgery,and the observation group received alteplase intrave-nous thrombolysis after bridging nerve interventional surgery.Hemodynamic indexes,National Institute of Health Stroke Scale(NIHSS)scores,Modified Rankin Scale(mRS)scores and bleeding conditions were compared between the two groups.Results After treatment,the hemodynamic indexes of both groups were improved,and the improve-ment degree of the observation group was better than that of the control group,the difference was statistically signifi-cant(P<0.05).After treatment,the NIHSS score and mRS score in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).The incidence of hemorrhage was 5.66%in the observation group and 9.43%in the control group,and there was no significant difference between the two groups(χ2=0.541,P>0.05).Conclusion Alteplase intravenous thrombolytic therapy combined with nerve interventional therapy can significantly improve the hemodynamics and neurological deficits in patients with acute ischemic stroke,with higher safety,and significantly reduce the incidence of bleeding after treatment.
万方数据
维普
