目的 探讨急性缺血性脑血管病单纯应用静脉溶栓与联合应用静脉溶栓与血管内介入治疗的疗效对比.方法 回顾性选取2021年3月—2022年3月南京市浦口人民医院收治的60例急性缺血性脑血管病患者的临床资料.按照不同治疗方法将患者分为联合组(30例)和单药组(30例),分别给予静脉溶栓联合血管内介入治疗和单纯静脉溶栓治疗.比较两组患者血液流变学指标、美国国立卫生研究院卒中量表(National In-stitutes of Health Stroke Scale,NIHSS)评分、改良Rankin量表(Modified Rankin Scale,MRS)评分及不良血管事件的发生率.结果 治疗后,联合组血浆黏度、红细胞聚集指数(1.91±0.16)mPa/s、(4.53±0.82)低于单药组(2.42±0.23)mPa/s、(5.14±1.16),差异有统计学意义(t=9.970、2.352,P均<0.05).治疗后,联合组NIHSS、MRS评分明显低于单药组,差异有统计学意义(P均<0.05).联合组不良血管事件发生率明显低于单药组,差异有统计学意义(P<0.05).结论 在急性缺血性脑血管病的临床治疗中,采用静脉溶栓与血管内介入联合治疗的方案,患者预后改善效果明显优于单纯静脉溶栓治疗,且不良血管事件发生率低.
Effectiveness of Intravenous Thrombolysis Combined with Endovascular Intervention in the Treatment of Acute Ischemic Cerebrovascular Disease and Its Impact on Prognosis
Objective To investigate the comparison of the efficacy of the application of intravenous thrombolysis alone and the combined application of intravenous thrombolysis and endovascular intervention for acute ischemic cere-brovascular disease.Methods The clinical data of 60 patients with acute ischemic cerebrovascular disease admitted to Nanjing Pukou People's Hospital from March 2021 to March 2022 were retrospectively selected.The patients were cat-egorized into combined group(30 cases)and monotherapy group(30 cases)according to different treatment methods,and were given intravenous thrombolysis combined with endovascular intervention and simple intravenous thromboly-sis treatment respectively.Blood rheology indexes,National Institutes of Health Stroke Scale(NIHSS)scores,Modified Rankin Scale(MRS)scores and the incidence of adverse vascular events were compared between the two groups.Re-sults After treatment,plasma viscosity and erythrocyte aggregation index of the combined group(1.91±0.16)mPa/s,(4.53±0.82)were lower than those of the monotherapy group(2.42±0.23)mPa/s,(5.14±1.16),and the differences were statistically significant(t=9.970,2.352,both P<0.05).After treatment,the NIHSS and MRS scores of the combined group were significantly lower than those of the monotherapy group,and the differences were statistically significant(both P<0.05).The incidence of adverse vascular events in the combined group was significantly lower than that in the monotherapy group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of acute ischemic cerebrovascular disease,the use of intravenous thrombolysis and endovascular intervention combined treatment program,the patients'prognosis is significantly better than that of intravenous thrombolysis alone,and the incidence of adverse vascular events is low.
万方数据
维普
