Role of Serum Cytokines in the Pathogenesis of Mycoplasma Pneumoniae Pneumonia in Children
Objective To explore the role of cytokines in the pathogenesis of refractory Mycoplasma pneumoniae pneu-monia in children.Methods The chinical datae 203 children with Mycoplasma pneumoniae pneumonia who were hos-pitalized in the Department of Pediatrics of Suzhou Hospital affiliated to Nanjing Medical University from July 2019 to June 2020 were retrospectively selected and divided into refractory Mycoplasma pneumoniae pneumonia(RMPP)group(n=26)and non-RMPP group(n=177).25 pairs of children were matched by propensity score matching analysis,correcting for confounders including gender,age,fever,wheezing,white blood cell and neutrophil counts,imaging and other characteristics(lobar/bronchopneumonia,pleural effusion,lung atelectasis).Compared serum cytokines[Serum interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ)]in two groups of children.Results IL-6[18.220(7.088,40.412)pg/mL],IL-10[7.335(4.838,11.690)pg/mL],and INF-γ[6.450(3.488,15.488)pg/mL]in the RMPP group were significantly higher than those in the non-RMPP group,and the differences were statistically significant(Z=1 426.000,1 176.000,1 438.000,all P<0.05).IL-10[7.840(4.755,11.690)pg/mL]in the matched RMPP group remained significantly higher than that in the non-RMPP group,and the difference was statistically significant(Z=173.500,P<0.05).Conclusion The results of this study showed a significant increase in IL-10 in the RMPP group,suggesting that IL-10 may play a role in the pathogenesis of RMPP.
万方数据
维普
