Efficacy and Safety Evaluation of Desloratadine Citrate in the Treatment of Chronic Urticaria
Objective To analyze the efficacy and safety of desloratadine citrate in the treatment of chronic urticaria(CU).Methods A total of 100 patients with CU admitted to Ganyu District People's Hospital of Lianyungang City from January 2022 to February 2023 were selected as the study objects and divided into two groups according to random number table method.The reference group(n=50)was given loratadine orally,and the observation group(n=50)was given deloratadine orally.The levels of inflammatory factors,therapeutic effect,symptom score of chronic urticaria,in-cidence of adverse drug reactions and coagulation index were compared between the two groups of patients.Results After 4 weeks of treatment,immunoglobulin E(IgE),interleukin-23(IL-23)and tumor necrosis factor-α(TNF-α)lev-els in the observation group were(92.24±7.93)U/mL,(25.36±2.94)ng/L and(20.26±3.67)ng/L,respectively,and lower than(115.95±13.68)U/mL,(30.98±3.81)ng/L and(26.45±4.71)ng/L in the reference group,and the differences were statistically significant(t=10.603,8.258,7.330,all P<0.05).The total effective rate of observation group was 94.00%,which was higher than that of reference group(78.00%),and the difference was statistically significant(χ2= 5.316,P<0.05).The CU symptom score of observation group was lower than that of reference group,and the difference was statistically significant(P<0.05).The incidence of adverse drug reactions in observation group was 6.00%,which was lower than that in reference group(22.00%),and the difference was statistically significant(χ2=5.316,P<0.05).The frequency of attack in observation group was less than that in reference group,and the duration of wind cluster was shorter than that in reference group,and the difference was statistically significant(both P<0.05).Conclusion In the treatment of CU,deloratadine citrate can improve the clinical symptoms of patients,reduce the level of inflamma-tory factors and the incidence of adverse reactions,improve the therapeutic effect,reduce the number of attacks and the duration of wind mass.
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