Clinical Value of Detecting Six Sex Hormones by CLIA in the Diagnosis of Female Reproductive Endocrine Diseases
Objective To investigate the clinical value of chemiluminescent immunoassay(CLIA)for detecting six sex hormones in the diagnosis of female reproductive endocrine diseases.Methods A total of 41 female patients with re-productive endocrine diseases who were treated in Ganyu District Maternal and Child Health Hospital of Lianyungang City from February 2021 to February 2023 were selected as the observation group,and 41 female health examination subjects during the same period were selected as the control group.Six items of sex hormones were detected by CLIA method,the sex hormone levels of the two groups were compared,and the changes of sex hormone levels in the obser-vation group in different menstrual cycles were analyzed.Results The levels of follicle stimulating hormone(FSH),lu-teinizing hormone(LH),prolactin(PRL),and testosterone(T)in the observation group were(22.15±3.21)mIU/mL,(47.32±4.36)mIU/mL,(185.36±3.51)ng/mL,and(0.79±0.11)ng/mL,respectively,which were higher than those in the control group[(13.50±2.17)mIU/mL,(6.27±1.54)mIU/mL,(13.22±2.62)ng/mL,(0.24±0.04)ng/mL],which were the levels of estradiol(E2)and progesterone(P)were(10.43±2.35)pg/mL and(0.05±0.01)ng/mL,respectively,lower than the control group's(22.22±4.64)pg/mL and(0.33±0.05)ng/mL,the difference was statistically significant(t=14.295,56.845,251.651,30.088,14.515,35.161,all P<0.001).In the observation group,the levels of sex hormones showed periodic changes in different menstrual cycles,and the levels of FSH and LH were lower in the follicular phase,the former slightly increased in the ovulation phase,but the difference was not statistically significant(P>0.05),while the latter showed a significant increase trend,and the two significantly decreased in the luteal phase,the difference was statistically significant(both P<0.05),the levels of PRL,T and P were increased,and the differences were statistically significant(all P<0.05).E2 levels increased with the development of follicles,and decreased rapidly in luteal phase,and the differences were statistically significant(both P<0.05).Conclusion The detection of six sex hormones by CLIA has obvious effect on the diagnosis of female reproductive endocrine diseases,and can provide certain guidance for clinical treatment.
Chemiluminescent immunoassay methodSix sex hormonesFemale reproductive endocrine diseasesDiagnosis
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