A Study of the Effect of Labetalol and Nifedipine in the Treatment of Se-vere Preeclampsia on Maternal and Perinatal Outcomes
Objective To explore the prognostic effects of nifedipine and labetalol on the treatment of severe pre-eclampsia on maternal and perinatal outcomes.Methods Seventy-eight patients with severe preeclampsia admitted to the obstetrics department of Xiangtan Maternal and Child Health Hospital from April 2021 to March 2023 were se-lected for the study,and were divided into control group and observation group by the random number table method,the control group(39 cases,treated with nifedipine),and the observation group(39 cases,treated with labetalol)com-paring maternal and perinatal conditions.Results The total effective rate of treatment in the observation group(94.87%)was higher than that in the control group(79.49%),the difference was statistically significant(χ2=4.129,P<0.05).Compared with the control group,the incidence of adverse pregnancy and perinatal outcomes,blood pressure in-dexes and 24-hour urine protein quantification decreased in the observation group,and 24-hour urine volume in-creased,the differences were statistically significant(all P<0.05).Conclusion In the treatment of severe preeclampsia,labetalol is more effective than nifedipine,which can improve the patient's blood pressure level and renal function sta-tus,prevent adverse maternal and infant outcomes,and has a lower rate of adverse reactions.
万方数据
维普
