Analysis of the Effect of Treatment with Hemoperfusion Combined with Hemodialysis in Patients with Diabetic Nephropathy and the Impact on In-flammatory Factors,Insulin Resistance
Objective To study and analyze the effect of hemoperfusion combined with hemodialysis in patients with diabetic nephropathy(DN)and the effect on inflammatory factors and insulin resistance.Methods A total of 80 DN patients admitted to Rizhao Central Hospital from January 2022 to September 2023 were selected as the research ob-jects.According to the odd and even number method,they were divided into the observation group and the control group,with 40 cases in each group.The control group was treated with hemodialysis,and the observation group was treated with hemoperfusion combined with hemodialysis.The two groups were compared before and after treatment tu-mor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-10(IL-10),insulin resistance index homa ir(HOMA-IR),fasting insulin(FINS),fasting plasma glucose(FPG)level changes and clinical efficacy.Results The ef-fective rate of the observation group(95.00%)was higher than that of the control group(77.00%),the difference was statistically significant(x2=5.165,P＜0.05).After treatment,the levels of TNF-α,CRP,IL-10,HOMA-IR,FINS and FPG in the observation group were significantly decreased,and the changes were higher than those in the control group,and the differences were statistically significant(all P＜0.05).The incidence of adverse reactions in the observa-tion group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclu-sion Compared with hemodialysis treatment alone,hemoperfusion combined with hemodialysis can significantly DN patients'therapeutic effects,reduce inflammatory factors,alleviate insulin resistance,and reduce the incidence of ad-verse reactions.
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维普
