Clinical Efficacy of Long-term Low-dose Azithromycin Combined with Ip-ratropium Bromide in Stable COPD Patients and Its Effect on Lung Func-tion
Objective To investigate the clinical effect of low-dose azithromycin combined with ipratropium bromide in the treatment of patients with stable chronic obstructive pulmonary disease.Methods Seventy patients with stable chronic obstructive pulmonary disease admitted to Department of Respiratory Medicine of Xuzhou Mining Hospital from June 2021 to December 2022 were selected as the study objects and were divided into control group and observa-tion group according to random number table method,with thirty-five patients in each group.Control group was treated with ipratropium bromide atomization,observation group was treated with low-dose azithromycin combined with ipratropium bromide atomization.The efficacy,force expiratory volume in one second,forced vital capacity,C re-active protein(CRP),procalcitonin(PCT),interleukin-6(IL-6)levels and adverse reaction occurrence were compared between the two groups.Results The curative effect of observation group was 94.29%,which was higher than that of control group(74.29%),and the difference was statistically significant(x2=5.285,P=0.022).After treatment,the levels of pulmonary function in observation group were higher than those in control group,while the levels of serum CRP,PCT and IL-6 in observation group were lower than those in control group,the difference was statistically significant(all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Low-dose azithromycin combined with ipratropium bromide atomization in patients with stable chronic obstructive pulmonary disease can improve the lung function and enhance the therapeutic effect.
万方数据
维普
