Effects of Edaravone Dexborneol Combined with Butylphthalide on In-flammatory Response and Neurological Function in Patients after Throm-bolysis for Acute Cerebral Infarction
Objective To explore the effects of edaravone dexborneol combined with butylphthalide on inflammatory response and neurological function in patients after thrombolysis for acute cerebral infarction.Methods A total of 84 patients with acute cerebral infarction admitted to Guizhou Nayong County People's Hospital from March 2022 to April 2023 were selected as the study objects and divided into two groups according to random number table method,with 42 patients in each group.The control group was treated with butylphthalein sodium chloride injection,and the observation group was treated with Edaravone dextrocamphorol on the basis of the control group.Both groups were treated for 2 weeks.Comparison of clinical efficacy,neurological deficits,ability of daily living,inflammatory factors[interleukin-8(IL-8),tumor necrosis factor α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],and the inci-dence of adverse reactions.Results The total effective rate of observation group was(95.24%)higher than that of con-trol group(80.95%),and the difference was statistically significant(x2=4.087,P＜0.05).After treatment,the Barthel in-dex score of the observation group was(79.47±6.04),higher than that of the control group.The National Institutes of Health Stroke Scale score(11.37±1.04)points,hs-CRP(8.03±1.82)mg/L,TNF-α(6.70±1.43)ng/L and IL-8(0.41±0.09)pg/mL levels were all lower than those of the control group,and the differences were statistically significant(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The treatment with edaravone dexborneol + butylphthalide in post-thrombolysis patients with acute cere-bral infarction can effectively reduce neurological impairment,inflammatory response,improve the ability to live,and is safe and reliable.
Acute cerebral infarctionEdaravone dexborneolButylphthalideInflammatory responseNeurological functionAbility of daily living
万方数据
维普
