Progress of Anti-hepatic Fibrosis Therapy Targeting Hepatic Stellate Cells
Hepatic fibrosis is the end result of repeated destruction and regeneration of hepatocytes during the devel-opment of chronic liver diseases,leading to excessive deposition of extracellular matrix in the liver.Hepatic stellate cell(HSC)is the main cell type in the fibrosis formation process in the injured liver,and some cytokines are involved.Currently,an important way to prevent and control liver fibrosis in the clinic is to inhibit the proliferation and activa-tion of HSC and promote HSC apoptosis.In this paper,we review the anti-hepatic fibrosis therapeutic regimen with HSC as the target.
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