头颈部鳞癌(Head and Neck Squamous Cell Carcinoma,HNSCC)为发生于口腔、咽、喉黏膜上皮的鳞癌,吸烟、酗酒与促进口腔及喉部鳞癌形成存在相关性,咽部鳞癌与人类乳头状瘤病毒感染有关.头颈部鳞癌有多种治疗方式,特别是以分子靶向治疗为代表的药物治疗快速发展.本文具体探讨与分析了头颈部鳞癌的流行病学状况,阐述了头颈部鳞癌的形成机制,综述了头颈部鳞癌的分子靶向治疗进展:西妥昔单抗、免疫检查点分子抑制剂、贝伐珠单抗.
Research Trends and New Advances in Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma(HNSCC)is a squamous carcinoma that occurs in the mucosal epithelium of the oral cavity,pharynx and larynx.Smoking and alcohol abuse are associated with the formation of squa-mous carcinoma of the oral cavity and larynx,and squamous cell carcinoma of the pharynx is associated with human papillomavirus infection.There are various treatment modalities for head and neck squamous cell carcinoma,espe-cially the rapid development of drug therapy represented by molecular targeted therapy.This article specifically dis-cusses and analyzes the epidemiological status of head and neck squamous cell carcinoma,describes the formation mechanism of head and neck squamous cell carcinoma,and reviews the progress of molecular targeted therapy for head and neck squamous cell carcinoma:cetuximab,immune checkpoint molecular inhibitors,and bevacizumab.
Head and neck squamous cell carcinomaMolecular targeted therapyImmune checkpoint molecular inhibitorsBevacizumabCetuximab
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