Research Trends and New Advances in Head and Neck Squamous Cell Carcinoma
张洪瑞 1苏本香 1庞艳 1孙月茹1
扫码查看
点击上方二维码区域，可以放大扫码查看
作者信息
1. 呼伦贝尔职业技术学院口腔教研室,内蒙古呼伦贝尔 021000
折叠
摘要
头颈部鳞癌(Head and Neck Squamous Cell Carcinoma,HNSCC)为发生于口腔、咽、喉黏膜上皮的鳞癌,吸烟、酗酒与促进口腔及喉部鳞癌形成存在相关性,咽部鳞癌与人类乳头状瘤病毒感染有关.头颈部鳞癌有多种治疗方式,特别是以分子靶向治疗为代表的药物治疗快速发展.本文具体探讨与分析了头颈部鳞癌的流行病学状况,阐述了头颈部鳞癌的形成机制,综述了头颈部鳞癌的分子靶向治疗进展:西妥昔单抗、免疫检查点分子抑制剂、贝伐珠单抗.
Abstract
Head and neck squamous cell carcinoma(HNSCC)is a squamous carcinoma that occurs in the mucosal epithelium of the oral cavity,pharynx and larynx.Smoking and alcohol abuse are associated with the formation of squa-mous carcinoma of the oral cavity and larynx,and squamous cell carcinoma of the pharynx is associated with human papillomavirus infection.There are various treatment modalities for head and neck squamous cell carcinoma,espe-cially the rapid development of drug therapy represented by molecular targeted therapy.This article specifically dis-cusses and analyzes the epidemiological status of head and neck squamous cell carcinoma,describes the formation mechanism of head and neck squamous cell carcinoma,and reviews the progress of molecular targeted therapy for head and neck squamous cell carcinoma:cetuximab,immune checkpoint molecular inhibitors,and bevacizumab.
关键词
头颈部鳞癌/分子靶向治疗/免疫检查点分子抑制剂/贝伐珠单抗/西妥昔单抗
Key words
Head and neck squamous cell carcinoma/Molecular targeted therapy/Immune checkpoint molecular inhibitors/Bevacizumab/Cetuximab
维普
万方数据