Study on the Predictive Value of Peripheral Blood Levels of NLR,PLR,and SII with Levels of γ-Aminobutyric Acid and Melatonin Concentration in OSAHS Patients
Objective To investigate the predictive value of peripheral blood neutrophil to lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammation index(SII)levels in relation to γ-aminobu-tyric acid and melatonin concentrations in obstructive sleep apnea hypoventilation syndrome(OSAHS).Methods Sixty OSAHS patients admitted to Guangxi Zhuang Autonomous Region Jiangbin Hospital from July 2020 to Decem-ber 2022 and 60 healthy physical examination volunteers were selected as study subjects.The differences in periph-eral blood NLR,PLR,and SII levels with γ-aminobutyric acid and melatonin concentrations were compared between the normal group and the OSAHS group,and the predictive value of each index for OSAHS was analyzed.Results Compared with the normal group,NLR,PLR,and SII levels were significantly higher and γ-aminobutyric acid and melatonin levels were significantly lower in the OSAHS group,and the differences were statistically significant(all P<0.05).And the joint prediction had the highest predictive accuracy for OSAHS,with an AUC value of 0.976(95%CI:0.955-0.997),sensitivity of 95.0%and specificity of 90.0%.Conclusion The joint detection of NLR,PLR,and SII levels with γ-aminobutyric acid and melatonin levels can reflect the systemic inflammation and sleep quality altera-tions in OSAHS.
万方数据
维普
