首页|早期血管介入栓塞治疗颅内动脉瘤对其疗效及神经功能的影响

早期血管介入栓塞治疗颅内动脉瘤对其疗效及神经功能的影响

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目的 探讨颅内动脉瘤的患者采取早期血管介入栓塞治疗的效果,并分析对神经功能的影响.方法 选取2021年3月—2023年3月在唐山市丰润区人民医院接受治疗的100例颅内动脉瘤患者为研究对象,按照双盲法对患者进行分组,即参照组与研究组,每组50例.参照组给予晚期(发病72 h后)血管介入栓塞治疗,研究组给予早期(发病72 h内)血管介入栓塞治疗,比较两组临床疗效、神经功能缺损程度、日常生活能力、血清炎性因子水平、并发症发生情况.结果 研究组临床总有效率(96.00%)明显高于参照组,差异有统计学意义(χ2=5.005,P=0.025).治疗后,研究组日常生活能力评分(90.35±4.73)分高于对照组,神经功能缺损程度评分(6.42±1.58)分低于对照组,差异有统计学意义(t=3.754、11.868,P均<0.05).治疗后,研究组白细胞介素-6水平(180.38±18.84)pg/mL、肿瘤坏死因子-α水平为(330.85±20.81)pg/mL显著低于对照组,白细胞介素-10水平为(23.19±3.80)pg/mL高于对照组,差异有统计学意义(t=5.257、4.804、4.550,P均<0.05).研究组并发症发生率(4.00%)明显低于参照组,差异有统计学意义(χ2=4.000,P=0.046).结论 颅内动脉瘤患者应用早期血管介入栓塞治疗的临床疗效更确切,不仅能够进一步改善神经功能与日常生活能力,还可以有效调节炎性因子水平,降低并发症发生率.
Effect of Early Vascular Intervention Embolization for Intracranial Aneu-rysm on Its Efficacy and Neurological Function
Objective To explore the effect of early vascular intervention embolization for patients with intracranial an-eurysms and to analyze the effect on neurological function.Methods A total of 100 patients with intracranial aneu-rysm who received treatment in Fenggrun District People's Hospital of Tangshan City from March 2021 to March 2023 were selected as the study objects,and the patients were divided into the reference group and the research group ac-cording to the double-blind method,with 50 cases in each group.The reference group was given late vascular inter-ventional embolization(72 h after the onset of disease),and the study group was given early vascular interventional em-bolization(within 72 h after the onset of disease).The clinical efficacy,degree of neurological impairment,ability of daily living,level of serum inflammatory factors,and incidence of complications of the two groups were compared.Results The total clinical effective rate of the study group(96.00%)was significantly higher than that of the reference group,the difference was statistically significant(χ2=5.005,P=0.025).After treatment,the score of daily living ability(90.35±4.73)points in the study group was higher than that in the control group,and the score of neurological impair-ment(6.42±1.58)points was lower than that in the control group,the differences were statistically significant(t=3.754,11.868,both P<0.05).After treatment,In the study group,the level of interleukin-6(180.38±18.84)pg/mL,and tumor necrosis factor-α(330.85±20.81)pg/mL were significantly lower than those of the control group,and the level of inter-leukin-10(23.19±3.80)pg/mL was significantly higher than that of the control group,the differences were statistically significant(t=5.257,4.804,4.550,all P<0.05).The complication rate in the study group(4.00%)was significantly lower than that in the control group,the difference was statistically significant(χ2=4.000,P=0.046).Conclusion The clinical effect of early vascular interventional embolization in intracranial aneurysm patients is more accurate,which can not only further improve nerve function and daily living ability,but also effectively regulate the level of inflamma-tory factors and reduce the incidence of complications.

Intracranial aneurysmEarly vascular intervention embolizationClinical efficacyNeurological functionDaily life abilityComplication

赵士军

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唐山市丰润区人民医院血管介入科,河北唐山 064000

颅内动脉瘤 早期血管介入栓塞 临床疗效 神经功能 日常生活能力 并发症

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(3)
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