Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Function in Elderly Patients Undergoing General Anesthesia
Objective To assess the effects of different doses of dexmedetomidine on postoperative cognitive function of elderly general anesthesia patients.Methods A total of 80 elderly patients who received general anesthesia in Huaining County People's Hospital from March 2022 to September 2023 were selected as the study objects and were divided into 3 groups by random number table method:control group(20 cases),group A(30 cases)and group B(30 cases).Control group was pumped with an equal dose of saline,while group A was pumped with 0.5 μg/kg dexmedeto-midine,and group B was pumped with 1.0 μg/kg dexmedetomidine.The anesthetic effects of the three groups were compared and analyzed.Results 24 h after surgery,the sedation scores of groups A and B was higher than that of the control group,and the score of group B[(3.99±0.11)points]was higher than that of group A[(2.51±0.91)points],the difference was statistically significant(all P<0.05).The pain score of groups A and B was lower than that of control group,and the score of group B[(0.70±0.09)points]was lower than that of group A[(0.91±0.28)points],and the differ-ence was statistically significant(all P<0.05).At 6 h and 1 d after operation,the cognitive function scores of groups A and B were better than those of control group,and group B was higher than group A,the difference was statistically significant(all P<0.05).In the immediate postoperative period and 1 day later,the levels of phosphatidylinositol 3-ki-nase(PI3K)and serine/threonine-protein kinase(AKT)in groups A and B were lower than those in the control group,group B was lower than group A,and the differences were statistically significant(all P<0.05).Conclusion In elderly general anesthesia patients,dexmedetomidine can significantly improve the cognitive function of patients and exert an-algesic and sedative effects,and the high dose of dexmedetomidine has a better protective effect on the cognitive abil-ity of patients.
万方数据
维普
