Clinical Significance of Prophylactic Application of Hepatoprotective Drugs in Antituberculosis Treatment
Objective To analyze the clinical significance of prophylactic application of hepatoprotective drug therapy in tuberculosis patients.Methods A prospective study was conducted on 120 newly treated tuberculosis pa-tients admitted to Xuzhou Infectious Disease Hospital from March 2020 to March 2021.The patients were divided into the observation group(n=60)and the control group(n=60)according to random number table method.On the ba-sis of normative anti-tuberculosis drug treatment,the patients in the observation group received preventive treatment of silybin meglumine tablets as hepatoprotective drugs,while the control group received normative anti-tuberculosis drug treatment only.The incidence of liver injury and liver function indexes(including glutamate aminotransferase,aspartate aminotransferase,glutamyl transpeptidase,alkaline phosphatase,total bilirubin)were compared between the two groups of patients.Results The incidence of liver injury in the observation group was 6.67%,significantly lower than that in the control group(18.33%),and the difference was statistically significant(χ2=5.087,P=0.024).After treatment,the serum levels of alanine aminotransferase,aspartate aminotransferase,glutamyl transpeptidase,alkaline phosphatase and total bilirubin in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).Conclusion The prophylactic application of hepatoprotective drug therapy in first-treatment tuberculosis patients can effectively reduce the incidence of antituberculosis drug-induced liver injury and the degree of liver injury.
万方数据
维普
