Clinical Effect of Sertraline Combined with Eszopiclone in the Treatment of Post-stroke Depression and the Impact on Sleep Quality
Objective To analyze the clinical effect of sertraline combined with dexzopiclone in patients with post-stroke depression,and explore the effect on sleep quality of patients.Methods A total of 72 patients with post-stroke depression admitted to the Department of Neurology of Chifeng Hospital from October 2020 to December 2022 were selected as the study objects.The group was divided into the reference group(n=36)and the study group(n=36)by single-blind grouping method.The reference group was treated with sertralin.The study group used sertraline com-bined with dexzopiclone as drug therapy for the patients,and compared the clinical therapeutic effect of the two groups of patients.Results The total effective rate of the study group(94.44%)was higher than that of the reference group,and the difference was statistically significant(χ2=6.400,P<0.05).After treatment,the serum central nerve spe-cific protein of the study group was significantly lower than that of the reference group,and the brain-derived neuro-trophic factor was significantly higher than that of the reference group,and the differences were statistically significant(both P<0.05).After treatment,the National Institute of Health Stroke Scale scores,Pittsburgh Sleep Quality Index scores,Hamilton Depression Scale scores,Hamilton Anxiety Scale scores of the study group were lower than those of the reference group,and the differences were statistically significant(all P<0.05).The hypersensitive C-reactive pro-tein in the study group was lower than that in the reference group,and the vascular endothelial growth factor was higher than that in the reference group,and the differences were statistically significant(both P<0.05).Conclusion The drug treatment of post-stroke depression patients with sertraline combined with eszopiclone can improve the pa-tients'neurological function and sleep quality,contribute to the enhancement of the patients'clinical therapeutic ef-fect,and have a positive significance in alleviating the patients'depressive symptoms.
StrokeDepressionSertralineEszopicloneSleep qualityNeurological function
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