Application Study of Early Awake Prone Position Combined with Trans-nasal High-flow Oxygen Therapy in the Treatment of Acute Respiratory Distress Syndrome
Objective To analyze the effect of application of early awake prone position combined with trans-nasal high-flow oxygen therapy in the treatment of acute respiratory distress syndrome(ARDS).Methods Fifty-two ARDS patients treated in the hospital of Guangxi Liugang Medical Co.,Ltd.from June 2022 to May 2023 were selected as the study objects,and were divided into control group(nasal high-flow oxygen therapy,n=25)and observation group(early awake prone position combined with nasal high-flow oxygen therapy,n=27)by random number table method.The oxy-genation indexes of the two groups were compared before treatment,24 h after treatment and 48 h after treatment.The intubation rate and length of ICU stay were compared between the two groups.The overall comfort and treatment com-pliance of the two groups were compared.Results Before treatment,there was no statistically significant difference in the oxygenation indexes between the two groups(all P>0.05).After 24 h of treatment,the oxygenation indexes of the two groups were significantly improved compared with that before treatment,the differences were statistically signifi-cant(all P<0.05),but there was no statistically significant difference between the two groups(all P>0.05).After 48 h of treatment,the oxygenation index of the two groups was significantly improved compared with that after 24 h of treat-ment,and the difference was statistically significant(all P<0.05).In the observation group,oxygenation index was(219.84±52.54)mmHg,oxygen partial pressure was(92.18±2.76)mmHg and arterial oxygen saturation was(94.47±2.06)%,which were higher than those in the control group[(190.46±49.37)mmHg,(90.14±3.25)mmHg,(93.23±1.84)%].The fraction of inspired oxygen in the observation group was(45.34±5.71)%,which was lower than that in the control group[(49.72±5.23)%],the differences were statistically significant(t=2.074,2.446,2.282,2.877,all P<0.05).The intubation rate and ICU stay days in the observation group were lower than those in the control group,and the differences were statistically significant(both P<0.05).Conclusion In the treatment of ARDS,early awake prone position combined with nasal high-flow oxygen therapy can improve the oxygenation of patients,and the longer the du-ration,the better the effect,the lower the intubation rate,and the shorter the length of ICU stay.
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