Application Value of Serum Tumor Markers in the Diagnosis of Lung Can-cer
Objective To analyze the clinical value of serum tumor markers in the diagnosis of lung cancer.Methods A total of 81 patients with lung cancer admitted to Liyang People's Hospital from January 2018 to December 2020 were selected as the observation group,81 patients with benign lung lesions were selected as the control group 1,and 81 healthy subjects were selected as the control group 2 during the same period.The levels of Squamous Cell Carci-noma Antigen(SCC),Carbohydrate Antigen 125(CA125),Carcinoembryonic Antigen(CEA)and Progastrin-releasing Peptide(ProGRP)in serum were determined by venous blood samples of the three groups.The difference between the three groups was compared and observed,and the Receiver Operator Characteristic(ROC)curve was drawn.The Area Under Curve(AUC)was used to evaluate the clinical efficacy of single and combined diagnosis of lung cancer.Results Serum levels of SCC,CA125,CEA and ProGRP markers in the observation group were(1.93±0.81)ng/mL,(33.10±9.29)U/mL,(13.46±5.37)ng/mL and(8.51±10.63)pg/ml,which were higher than those of the control group.The differences were statistically significant(t=6.508,12.840,14.547,20.426,all P<0.05).According to ROC curve analysis,AUC values of SCC,CA125,CEA and ProGRP were all over 0.7.AUC value of combined diagnosis was the highest(0.840).Sensitivity,specificity and Yoden index were also higher than those of single diagnosis.Conclusion In the clinical diagnosis of lung cancer,SCC,CAI25,CEA and PROGRP serum tumor markers can provide valuable laboratory evidence.The combined method has higher diagnostic efficiency.
万方数据
维普
