Effect of Intracoronary Injection of Recombinant Human Prourokinase in Combination with Sodium Nitroprusside Tirofiban on the Efficacy of PCI in STEMI Patients with High Thrombotic Load
Objective To analyze the effect of intracoronary injection of recombinant human prourokinase combined with sodium nitroprusside tirofiban on the efficacy of percutaneous coronary intervention(PCI)in patients of ST-segment elevation myocardial infarction(STEMI)with high thrombus load.Methods 82 patients with high thrombus load STEMI admitted to Lianyungang Hospital of Traditional Chinese Medicine from January 2022 to June 2023 who needed PCI were selected as study objects,and were divided into study group and control group according to the ran-domized table method,with 41 cases in each group.In the control group,sodium nitroprusside and tirofiban were ap-plied for intracoronary injection,and the study group was given recombinant human prourokinase on the basis of the control group.Cardiac function indexes,the occurrence of bleeding events,and the occurrence of postoperative compli-cations were compared in the two groups.Results At each postoperative time point,the left ventricular end-diastolic internal diameter of the study group was lower than that of the control group,and the left ventricular ejection fraction was higher than that of the control group,and the differences were statistically significant(both P<0.05).The compli-cation rate of the study group(9.76%)was lower than that of the control group(26.83%),and the difference was statis-tically significant(χ2=3.998,P<0.05).There was no statistically significant difference in bleeding rate between the two groups(P>0.05).Conclusion Recombinant human prourokinase combined with sodium nitroprusside,tirofiban intra-coronary injection,can improve the high thrombus load STEMI patients undergoing PCI process center function,re-duce postoperative complications,and does not increase the risk of bleeding.
Recombinant human prourokinaseSodium nitroprussideTirofibanHigh thrombus loadComplicationsBleeding rate
NETL
NSTL
万方数据
维普
