Clinical Study of One-time Insulin Shock Therapy for Diabetic Ketoacido-sis in Emergency
Objective To explore the clinical effect of one-time insulin shock treatment for diabetic ketoacidosis in emergency.Methods Sixty-six diabetic ketoacidosis cases from the emergency department of Luhe County People's Hospital of Shanwei City from September 2022 to September 2023 were selected and divided into control group and observation group according to different insulin administration regiments.The control group(n=33)was treated with small dose of insulin continuously,and the observation group(n=33)was treated with one-time insulin shock therapy.The total effective rate,remission time and improvement of related indexes were compared between the two groups.Results There was no statistically significant difference in the total effective rate between the two groups(P>0.05).In the observation group,it took(13.97±3.80)h for blood glucose to reach the standard,(24.61±5.20)h for urine ketone body to turn negative,and(12.48±1.73)h for blood pH value to return to normal,they were significantly shorter than the control group,and the differences were statistically significant(t=5.877,6.095,10.666,all P<0.05).After treat-ment,blood β-hydroxybutyric acid and blood lactic acid levels in two groups were significantly decreased compared with those before treatment,and the differences were statistically significant(both P<0.05),but there was no statisti-cally significant difference between two groups(both P>0.05).After 2 d treatment,the levels of creatine kinase(20.66±2.52)U/L,creatine kinase isozyme(68.30±4.37)U/L and aspartate aminotransferase(31.90±2.77)U/L in the observa-tion group were better compared with those in the control group,and the differences were statistically significant(t= 2.394,3.357,2.369,all P<0.05).There was no statistically significant difference in the total incidence of adverse reac-tions between the two groups(P>0.05).Conclusion Compared with the continuous drip of small dose of insulin,one-time impact of insulin in emergency treatment of diabetic ketoacidosis can control the disease faster,relieve the symp-toms of patients,and do not cause serious adverse reactions.
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万方数据
维普
