阿托伐他汀钙辅助治疗脑梗死后认知功能障碍的临床效果分析
Clinical Effect of Atorvastatin Calcium in the Treatment of Cognitive Dys-function after Cerebral Infarction
许佳程 1裴琳1
作者信息
- 1. 江苏省宜兴市第六人民医院药剂科,江苏宜兴 214211
- 折叠
摘要
目的 探析阿托伐他汀钙用于脑梗死后认知功能障碍辅助治疗中的价值.方法 选取江苏省宜兴市第六人民医院于2021年1月—2023年6月收治的80例脑梗死后认知功能障碍患者为对象,按随机数表法分为对照组(n=40,应用氯吡格雷治疗)和研究组(n=40,对照组基础上应用阿托伐他汀钙辅助治疗),对比两组患者临床总有效率、不良反应发生率,神经功能缺损、认知功能、日常生活质量、日常生活能力评分及血脂水平.结果 研究组总有效率(95.00%)较对照组高(80.00%),差异有统计学意义(χ2=4.114,P<0.05).治疗前,两组神经功能缺损、认知功能、日常生活质量及日常生活能力评分比较,差异无统计学意义(P均>0.05),治疗后,研究组神经功能缺损评分低于对照组,认知功能、日常生活质量及日常生活能力评分均高于对照组,血脂水平(胆固醇、三酰甘油、低密度脂蛋白水平及高密度脂蛋白)均优于对照组,差异有统计学意义(P均<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 阿托伐他汀钙辅助用于脑梗死后认知功能障碍的治疗,效果显著.
Abstract
Objective To explore the value of atorvastatin calcium in the adjuvant treatment of cognitive dysfunction after cerebral infarction.Methods A total of 80 patients with cognitive dysfunction after cerebral infarction from the pharmacy department of Yixing Sixth People's Hospital Jiangsu Province from January 2021 to June 2023 were se-lected as the study objects.Random number table method was used to divide them into the control group(n=40,clopi-dogrel treatment)and the study group(n=40,atorvastatin calcium assisted treatment on the basis of control group).The total clinical effective rate,incidence of adverse reactions,neurological impairment,cognitive function,quality of daily life,ability of daily living scores and blood lipid level were compared between the two groups of patients.Results The total effective rate of the study group(95.00%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ2=4.114,P<0.05).There were no statistically significant differences in the scores of neu-rological impairment,cognitive function,quality of daily life and ability of daily living between two groups before treat-ment(all P>0.05).The score of neurological impairment in the study group after treatment was lower than that in con-trol group,the score of cognitive function,quality of daily life and ability of daily living after treatment was higher than those in control group,and blood lipid levels(cholesterol,triglyceride,low density lipoprotein and high density lipopro-tein)in the study group were better than those in the control group after treatment,and the difference was statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between groups(P>0.05).Conclusion Atorvastatin calcium assisted in the treatment of cognitive dysfunction after cerebral in-farction can acheive a significant effect.
关键词
阿托伐他汀钙/脑梗死/认知功能障碍Key words
Atorvastatin calcium/Cerebral infarction/Cognitive dysfunction引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据