Study on the Factors Influencing the Efficacy of Percutaneous Vertebro-plasty Treatment in Elderly Osteoporotic Vertebral Compression Fracture Patients
Objective To study the factors affecting the efficacy of percutaneous vertebroplasty(PVP)in the treatment of elderly osteoporotic vertebral compression fracture(OVCF)patients.Methods Three hundred patients with ad-vanced OVCF admitted to Guizhou Hospital of Beijing Jishuitan Hospital from January 2020 to December 2022 were selected as the study subjects.All patients were treated with PVP.They were divided into the poor efficacy group(n= 41)and the good efficacy group(n=259)according to the difference in efficacy.The baseline data,treatment and se-rum 25-hydroxy vitamin D[25-(OH)D],bone alkaline phosphatase(BALP)and bone gla protein(BGP)levels were compared between the two groups.A multifactorial logistic regression analysis was performed to clarify the factors af-fecting the poor efficacy of PVP treatment in elderly OVCF patients.Results The poor distribution of bone cement,the proportion of bone cement leakage,preoperative visual simulation score,preoperative serum BALP and BGP levels in the poor efficacy group were higher than those in the good efficacy group,and the preoperative 25-(OH)D level in the poor efficacy group was lower than that in the good efficacy group,the differences were statistically significant(all P<0.05).Multivariate Logistic regression analysis confirmed that the risk factors for poor efficacy of PVP in elderly OVCF patients included poor distribution of bone cement,bone cement leakage,preoperative VAS score,preoperative BALP,preoperative BGP(OR=1.526,1.692,2.015,2.501,2.712,all P<0.05),the preoperative serum 25-(OH)D was the protective factor(OR=0.615,P<0.05).Conclusion The efficacy of elderly OVCF patients after PVP treatment was affected by poor cement distribution,cement leakage,preoperative VAS score and preoperative serum 25-(OH)D,BALP and BGP levels.
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