目的 探究吡拉西坦注射液联合甘露醇在脑外伤后脑水肿患者中的应用效果.方法 选取2021年1月—2023年6月镇江市丹徒区人民医院重症医学科收治的30例脑外伤后脑水肿患者为研究对象,按照不同用药方法分为A组和B组,每组15例.A组接受甘露醇治疗,B组接受吡拉西坦注射液联合甘露醇治疗.对比两组临床疗效,包括临床总有效率、神经功能缺损程度、用药安全性.结果 用药7 d后B组的临床总有效率(93.33%)高于A组(73.33%),差异无统计学意义(P>0.05).用药前,两组美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分比较,差异无统计学意义(P>0.05);用药7 d后,两组NIHSS评分较用药前低,差异有统计学意义(P<0.05).用药7 d后,B组NIHSS评分为(11.11±2.09)分,低于A组的(16.27±3.15)分,差异有统计学意义(t=5.287,P<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 吡拉西坦注射液联合甘露醇的整体效果较单一药物更理想,其有利于患者受损神经功能的修复、认知功能的恢复及生活质量水平的进一步提升,且不增加不良反应发生风险.
Application of Piracetam Injection Combined with Mannitol in Patients with Cerebral Edema after Traumatic Brain Injury
Objective To investigate the application effect of piracetam injection combined with mannitol in patients with cerebral edema after traumatic brain injury.Methods Thirty patients with cerebral edema after traumatic brain injury admitted to the Department of Intensive Care Medicine of Dantu District People's Hospital of Zhenjiang City from January 2021 to June 2023 were selected as the study objects,and they were divided into group A and group B according to different medication methods,with 15 cases in each group.Group A received mannitol treatment,group B received piracetam injection combined with mannitol treatment.The clinical efficacy of the two groups was compared,including the total clinical effective rate,the degree of neurological impairment and the safety of medication.Results The total clincal effective rate of group B(93.33%)was higher than that of group A(73.33%)after 7 d of treatment,and the difference was not statistically significant(P>0.05).Before medication,there was no statistically significant difference in the score of National Institutes of Health Stroke Scale(NIHSS)between the two groups(P>0.05).After 7 d of treatment,the score of the NIHSS was lower in the two groups than before treatment,and the difference was statis-tically significant(P<0.05).After 7 d of treatment,the score of NIHSS(11.11±2.09)points in group B was lower than that in group A(16.27±3.15)points,and the difference was statistically significant(t=5.287,P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclu-sion The overall effect of piracetam injection combined with mannitol is more ideal than that of single drug,which is conducive to the repair of damaged nerve function,the recovery of cognitive function and the further improvement of quality of life in patients,and does not increase the risk of adverse reactions.
Cerebral edema after traumatic brain injuryMannitolPiracetam injectionApplication effect
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