Analysis of the Effectiveness of the Application of Dapagliflozin Combined with Angiotensin-converting Enzyme Inhibitors in the Clinical Treatment of Patients with Proteinuria in Diabetic Nephropathy
Objective To analyze the effect of dapagliflozin combined with angiotensin-converting enzyme inhibitor in the clinical treatment of proteinuria patients with diabetic nephropathy.Methods A total of 78 patients with diabetic nephropathy admitted to Suining County People's Hospital from January 2021 to March 2023 were selected as the study objects,and were divided into two groups according to random number table method.The control group(n=38)was treated with angiotensin-converting enzyme inhibitor(Benazepril hydrochloride tablet),and the observation group(n=40)was treated with daglipzin on the basis of the control group.Urine microprotein(mALB),24 h urinary protein,serum albumin(ALB)level,blood glucose level and complications were compared between the two groups before and after treatment.Results The mALB[(167.12±23.15)mg/L]and urinary protein quantity[(1.04±0.28)g/24 h]in obser-vation group were lower than those in control group[(342.52±35.26)mg/L and(1.72±0.62)g/24 h],and the differences were statistically significant(both P<0.05).Serum ALB level[(33.74±1.16)g/L]was higher than that of control group[(31.93±0.85)g/L],and the difference was statistically significant(P<0.05).After treatment,fasting plasma glucose[(5.16±1.67)mmol/L]in the observation group was lower than that in the control group[(6.69±2.24)mmol/L],and 2 h postprandial blood glucose[(6.59±2.05)mmol/L]was lower than that in the control group[(8.76±3.25)mmol/L],and glycosylated haemoglobin[(4.35±1.86)%]was lower than control group[(6.26±2.85)%],and the differences were statistically significant(t=3.432,3.546,3.522,all P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of diabetic nephropathy proteinuria,the application of daglipzin combined with angiotensin-converting enzyme inhibitors is more significant.
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