目的 研究探讨乙肝孕妇大三阳和小三阳状态中乙型肝炎病毒(Hepatitis B virus,HBV)DNA载量、肝功能指标、肝纤维化标志物含量及不同HBVDNA载量孕妇的肝功能水平.方法 选取临清市人民医院于2020年1月—2023年1月收治的120例乙肝孕妇作为研究对象,根据乙肝两对半检测结果将其分为两组,即大三阳组(n=60)和小三阳组(n=60).比较两组HBVDNA载量、肝功能指标、肝纤维化标志物含量及不同HBVDNA载量孕妇的肝功能指标、肝纤维化标志物含量.结果 大三阳组丙氨酸转移酶水平(29.00±7.62)U/L、HBVDNA水平(5.18±1.16)×104 U/mL均高于小三阳组的(26.00±2.85)U/L、(2.08±1.11)×104 U/mL,差异有统计学意义(t=2.856、14.956,P均<0.05).大三阳组的重组人几丁质酶3样蛋白1水平低于小三阳组,差异有统计学意义(P<0.05).伴随着HBVDNA载量上升,两组患者甲胎蛋白水平随之增加,但是在同等HBADNA载量下,两组甲胎蛋白水平比较,差异无统计学意义(P>0.05).结论 开展孕前抗乙肝病毒诊疗、孕期风险系数评估,采取科学有效的干预措施,均能够有效抑制乙肝在母婴中的传播.
Analysis of Liver Function Indicator Levels in Pregnant Women with Hepatitis B Da Sanyang and Xiao Sanyang and Different HBVDNA Loads
Objective To investigate the content of Hepatitis B virus(HBV)DNA load,liver function index and liver fibrosis marker in pregnant women with hepatitis B Da Sanyang and Xiao Sanyang and the liver function of them with different HBVDNA loads.Methods A total of 120 pregnant women with hepatitis B admitted to Linqing People's Hos-pital from January 2020 to January 2023 were selected as the study objects,and divided into two groups according to the results of two-half hepatitis B detection,namely Da Sanyang group(n=60)and Xiao Sanyang group(n=60).The contents of HBVDNA load,liver function index and liver fibrosis marker were compared between the two groups and the contents of liver function index and liver fibrosis marker of pregnant women with different HBVDNA load.Results The alanine aminotransferase level(29.00±7.62)U/L and HBVDNA level(5.18±1.16)×104 U/mL in Da Sanyang group were higher than those in Xiao Sanyang group(26.00±2.85)U/L and(2.08±1.11)×104 U/mL,and the differences were statistically significant(t=2.856,14.956,both P<0.05).The recombinant human chitinase-like protein 1 level in Da Sanyang group was lower than that in Xiao Sanyang group,and the difference was statistically significant(P<0.05).With the increase of HBVDNA load,alpha-fetoprotein level increased between the two groups,but there was no statis-tically significant difference in alpha-fetoprotein level between the two groups under the same HBADNA load(P>0.05).Conclusion Pre-pregnancy anti-HBV diagnosis and treatment,pregnancy risk coefficient assessment,scientific and effective intervention measures can effectively inhibit the transmission of hepatitis B in mother and child.
Hepatitis B pregnant womenDa sanyangXiao sanyangHepatitis B virus DNA loadLiver function indexLiver fibrosis marker content
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