Research Progress on the Role and Molecular Mechanisms of C-reactive Protein in Cervical Cancer
Cervical cancer is one of the common malignant tumors of the female reproductive system.Although vari-ous experimental techniques have been adopted in clinical practice to screen early cervical lesions,the morbidity and mortality of cervical cancer are still high.C-reactive protein(CRP)is a positive acute phase reaction protein,which in-creases sharply in the body during infection or inflammation,and shows diagnostic and prognostic value in different types of malignant tumors.Recent studies have shown that CRP can be used to assess cervical cancer prognosis,ob-serve efficacy,and predict complications,and that CRP testing can help identify patients at increased risk of cervical cancer progression and associated death.Its molecular mechanism mainly includes the regulation of CRP anti-tumor immunity,oncogene expression,chemotherapy resistance and other processes,involving many signaling pathways such as phosphoinositol 3-kinase/protein kinase B(PI3K/Akt),extracellular signal-regulated kinase(ERK),nuclear factor-κB(NF-κB).This article reviewed the latest progress of relevant research and looks forward to the future development direction of this field,which will help guide the cervical cancer screening based on CRP detection and the new cervi-cal cancer treatment targeting CRP.
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