Research Status of the Anti-tumor Mechanism of Honokiol
Magnolia officinalis is a traditional Chinese medicine,and honokiol(HNK)is the main active component of magnolia officinalis.HNK has a wide range of pharmacological effects,such as antibacterial,anti-inflammatory,an-tioxidant,angiogenic inhibition,anti-spasticity,anti-depression,antiviral and anti-tumor.In particular,its remark-able anti-tumor effect has been widely concerned.As a natural source and highly safe anti-tumor active ingredient,HNK mainly exerts anti-tumor effects through mechanisms such as inducing apoptosis of tumor cells,blocking tumor cell cycle,inhibiting proliferation and metastasis of tumor cells,inducing autophagy,activating endoplasmic reticulum stress and inducing reactive oxygen production.In this paper,the anti-tumor effects and mechanisms of HNK were summarized and analyzed based on the literature on HNK at home and abroad in recent years,in order to provide some reference for the further development of new drugs and clinical application of HNK.
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