Efficacy of Rosuvastatin Combined with Clopidogrel in the Treatment of Unstable Angina Pectoris of Coronary Heart Disease
Objective To investigate the efficacy and safety of rosuvastatin combined with clopidogrel in the treatment of unstable angina pectoris in patients with coronary atherosclerotic heart disease(CHD).Methods 116 cases of un-stable angina patients with coronary heart disease admitted to Dongtai Hospital of Traditional Chinese Medicine from March 2021 to December 2022 were selected for the study,all of which were treated with conventional drugs(such as aspirin enteric-coated tablets + metoprolol tartrate + low molecular heparin),and were divided into 2 groups by ran-domized feeler-ball method,with 58 cases in each group.The control group were given simvastatin combined with clopidogrel after conventional treatment,and the treatment group were given rosuvastatin combined with clopidogrel af-ter conventional treatment.Comparing the effectiveness of treatment,angina attack,lipid index,and safety of the two groups.Results The effectiveness of the treatment group was 96.55%higher than 86.21%in the control group,and the difference was statistically significant(χ2=3.940,P<0.05).After 6 weeks of treatment,the frequency and duration of angina attacks in the treatment group were significantly less than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the levels of triacylglycerol,total cholesterol and low-density lipoprotein cholesterol in the treatment group were significantly lower than those in the control group,and the level of high-density lipoprotein cholesterol was significantly higher than that in the control group,the differences were statistically significant differences(all P<0.05).The incidence of adverse reactions in the treatment group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Treatment of patients with unstable angina in coronary artery disease with rosuvastatin combined with clopidogrel therapy canreduce angina attacks,shorten duration,control lipid levels,and also has a certain degree of safety and canreduce adverse reactions.
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NSTL
万方数据
维普
