Clinical Safety Study of Nifedipine Combined with Magnesium Sulfate in the Treatment of Hypertensive Disorder Complicating Pregnancy
Objective To analyze the safety of nifedipine + magnesium sulfate treatment for hypertensive disorder complicating pregnancy(HDCP).Methods A total of 83 cases of HDCP patients admitted to Rizhao Central Hospital from November 2020 to November 2023 were selected as the study objects.They were divided into the ordinary group(n=41)and investigation group(n=42)by random number table method.The ordinary group was treated with magne-sium sulfate,and the investigation group was treated with combined nifedipine.The blood pressure indexes,uterine blood flow,and renal function were compared,and the safety was assessed between the two groups.Results After treat-ment,the levels of diastolic and systolic blood pressure of two groups were decreased,the investigation group of(71.36±4.98)mmHg and(118.02±7.07)mmHg were lower than those in the ordinary group,and the differences were statistically significant(t=8.028,6.988,both P<0.05).The beating index,resistance index,and peak systolic flow rate of two groups were decreased after treatment,the investigation group was lower than the ordinary group,and the differ-ences were statistically significant(both P<0.05).After treatment,creatinine and 24 h urine proteins of two groups were decreased,the investigation group was lower than the ordinary group,and the differences were statistically signifi-cant(both P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Nifedipine + magnesium sulfate has a certain degree of safety,can reduce blood pressure,improve the blood flow in the uterine position of each HDCP patient,and can also prevent kidney damage.
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NSTL
万方数据
维普
