目的 分析2型糖尿病(Diabetes Mellitus Type 2,T2DM)肥胖型患者采用沙格列汀与利拉鲁肽联合治疗的效果.方法 选取2022年9月—2023年8月济南市章丘区中医医院收治的94例T2DM肥胖型患者,按照随机数表法分为研究组和对照组,各47例.研究组采用沙格列汀与利拉鲁肽联合治疗,对照组仅采用沙格列汀治疗.对比两组血糖值、体质指数(Body Mass Index,BMI)、腰围、胰岛功能指标以及不良反应.结果 研究组治疗12周后空腹血糖(7.52±1.50)mmol/L低于对照组(9.56±1.46)mmol/L,差异有统计学意义(t=6.681,P<0.05),研究组餐后2 h血糖、糖化血红蛋白值较对照组低,且胰岛功能优于对照组,差异有统计学意义(P均<0.05).与治疗12周后的对照组结果对比,研究组的BMI与腰围值更低,差异有统计学意义(P均<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论 T2DM肥胖型患者采用沙格列汀与利拉鲁肽联合治疗不仅可以改善血糖值与胰岛功能,且降低了BMI与腰围,安全性较为理想.
Effect of Saxagliptin and Liraglutide in the Treatment of Type 2 Diabetic Obese Patients
Objective To analyze the effect of saxagliptin combined with liraglutide in obese patients with type 2 dia-betes mellitus(T2DM).Methods 94 obese patients with T2DM admitted to Zhangqiu District Hospital of Traditional Chinese Medicine in Jinan City from September 2022 to August 2023 were selected and divided into a study group and a control group according to the method of random number table,each with 47 cases.The study group was treated with the combination of saxagliptin and liraglutide,and the control group was treated with saxagliptin only.Blood glu-cose,body mass index(BMI),waist circumference,islet function indexes and adverse reactions were compared be-tween the two groups.Results Fasting blood glucose(7.52±1.50)mmol/L in the study group was lower than that in the control group(9.56±1.46)mmol/L after 12 weeks of treatment,the difference was statistically significant(t=6.681,P<0.05).The 2 h postprandial blood glucose and glycosylated hemoglobin values were lower in the study group than those in the control group,the islet function indexes were better than those of the control group,and the differences were statistically significant(all P<0.05).Compared with the control group after 12 weeks of treatment,BMI and waist circumference were lower in the study group,the differences were statistically significant(both P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination treatment of saxagliptin and liraglutide in T2DM obese patients can not only improve blood glucose and islet function,but also reduce BMI and waist circumference,which is relatively safe.
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