首页|非小细胞肺癌患者接受安罗替尼联合华蟾素治疗的疗效及安全性研究

非小细胞肺癌患者接受安罗替尼联合华蟾素治疗的疗效及安全性研究

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目的 分析安罗替尼联合华蟾素在非小细胞肺癌(Non-small Cell Lung Cancer,NSCLC)治疗中的效果.方法 选取常熟市第二人民医院于2020年1月—2023年3月收治的109例NSCLC患者为研究对象,采用随机数表法分为对照组(n=54)、研究组(n=55).对照组给予安罗替尼联合多西他赛注射液化疗,研究组给予安罗替尼联合华蟾素片化疗.比较两组症状缓解情况、肿瘤标志物水平、不良反应发生率.结果 研究组症状缓解率高于对照组,肿瘤标志物水平低于对照组,差异有统计学意义(P均<0.05);研究组不良反应发生率(1.82%)低于对照组(11.11%),差异有统计学意义(χ2=3.916,P<0.05).结论 安罗替尼和华蟾素联合治疗NSCLC效果显著,能够促进疾病缓解,降低肿瘤标志物水平,且不良反应发生风险较低,为NSCLC治疗提供了有效的治疗方案.
Efficacy and Safety of Patients with Non-small Cell Lung Cancer Treated with Anlotinib Combined with Cinobufagin
Objective To analyze the efficacy of anlotinib combined with cinobufagin in the treatment of non-small cell lung cancer(NSCLC).Methods A total of 109 NSCLC patients admitted to the Second People's Hospital of Changshu City from January 2020 to March 2023 were selected as the study objects,and were divided into control group(n=54)and study group(n=55)by random number table method.The control group was given antirotinib com-bined with docetaxel injection chemotherapy,and the study group was given antirotinib combined with cinobufagin tab-lets.Symptom relief,tumor marker level and incidence of adverse reactions were compared between the two groups.Results The symptom remission rate of the study group was higher than that of the control group,and the level of tu-mor markers were lower than those of the control group,and the differences were statistically significant(all P<0.05).The adverse reaction rate in the study group(1.82%)was lower than that in the control group(11.11%),and the differ-ence was statistically significant(χ2=3.916,P<0.05).Conclusion The combined treatment of anlotinib and cinobufa-gin has a significant effect on NSCLC,can promote disease remission and reduce the level of tumor markers,and has a low risk of toxic and side effects,providing an effective treatment plan for NSCLC.

Non-small cell lung cancerAnlotinibCinobufaginChemotherapyTumor markersAdverse reaction

黄锦宏、陈虹、程易、由振华、周秀芬

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常熟市第二人民医院呼吸与危重症医学科,江苏常熟 215500

非小细胞肺癌 安罗替尼 华蟾素 化疗 肿瘤标志物 不良反应

2024

系统医学

系统医学

ISSN:
年,卷(期):2024.9(7)
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