Application of the Combination of Alfacalcidol and Cinacalcet in Patients with Secondary Hyperparathyroidism on Hemodialysis
Objective To analyze the effect of hemodialysis patients with secondary hyperparathyroidism according to the combination of alfacalcitol and cinacalcet.Methods A total of 96 patients with secondary hyperparathyroidism on hemodialysis who were admitted to the Hemodialysis Unit of Huishui County People's Hospital were selected from Oc-tober 2021 to October 2023,and they were randomly sorted and divided into the control group(48 cases,treated with conventional protocols)and the observation group(48 cases,treated with alfacalcitol and cinacalcet).The serum in-dexes related to parathyroid hormone and safety were compared between the two groups.Results Comparing Blood cal-cium,blood phosphorus and the whole segment parathyroid hormone level before treatment between two groups,and the differences were not statistically significant(all P>0.05).After treatment,the blood calcium in the observation group was(2.30±0.08)mmol/L,which was higher than that of the control group(2.10±0.11)mmol/L,and the difference was statistically significant(t=4.253,P<0.05).The level of blood phosphorus and total parathyroid hormone in the ob-servation group were significantly lower than the observation group,and the differences were statistically significant(both P<0.05).Comparing alanine aminotransferase as well as aspartate aminotransferase levels before and after treat-ment between the two groups,and the differences were not statistically significant(all P>0.05).And the incidence of adverse reactions between the two groups were compered,and the difference was not statistically significant(P>0.05).Conclusion Hemodialysis patients with secondary hyperparathyroidism treated with alfacalcitol and cinacalcet can regulate the levels of blood calcium,blood phosphorus,and all-segment parathyroid hormone,and it will not affect the patients'liver function and renal function,with high safety.
NETL
NSTL
万方数据
