Effects of Vitamin D Calcium Chewable Tablets Combined with Zole-dronic Acid on Symptom Improvement and Serum Inflammatory Factor Levels of Osteoporosis
Objective To analyze the effects of vitamin D calcium chewable tablets combined with zoledronic acid on the improvement of osteoporosis symptoms and the level of serum inflammatory factors.Methods Sixty-two patients with osteoporosis admitted to Caoxian People's Hospital from March 2019 to March 2023 were selected as the study objects,and they were divided into control group(n=31,zoledronic acid treatment)and observation group(n=31,vita-min D calcium chewable tablets combined with zoledronic acid treatment)by random number table method.Symptom improvement time and serum inflammatory factor levels were compared between the two groups.Results The improve-ment time of fatigue,low back pain and bone pain in the observation group was(5.55±1.85),(7.42±1.63),(8.07±1.93)d,respectively,which was shorter than that of the control group(7.32±1.23),(11.18±2.72),(13.96±2.67)d,and the differ-ences were statistically significant(t=3.097,4.693,5.263,all P<0.05).Before treatment,there were no significant dif-ference in the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)],bone mineral density(BMD)and 25 hydroxyvitamin D(all P>0.05).After treatment,the levels of inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).BMD and 25-hydroxyvitamin D in both groups were higher than those before treatment,and BMD and 25-hydroxyvitamin D in observation group were higher than those in control group,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Vitamin D calcium chewable tablets combined with zole-dronic acid can better improve the clinical symptoms of osteoporosis patients,reduce the level of serum inflammatory factors,improve the level of bone mineral density and bone metabolism.
Vitamin D calcium chewable tabletsZoledronic acidOsteoporosisSerum inflammatory factor
NETL
NSTL
万方数据
