沙库巴曲缬沙坦钠联合琥珀酸美托洛尔治疗心力衰竭疾病的价值分析
Analysis of the Value of Sacubitril Valsartan Sodium Combined with Meto-proprool Succinate in the Treatment of Heart Failure
刘辉海 1李国辉2
作者信息
- 1. 惠民县人民医院心血管科,山东滨州 251700
- 2. 惠民县人民医院心内科,山东滨州 251700
- 折叠
摘要
目的 分析心力衰竭疾病治疗中,沙库巴曲缬沙坦钠、琥珀酸美托洛尔联合治疗方案的应用价值.方法 选取2021年1月—2023年6月惠民县人民医院收治的80例慢性心力衰竭患者为研究对象,以盲选法随机分为两组.对照组(40例)接受沙库巴曲缬沙坦钠治疗,观察组(40例)在对照组基础上增加琥珀酸美托洛尔治疗.对比两组左心室射血分数(Left Ventricular Ejection Fraction,LVEF)、B型脑钠肽(B-type Natriuretic Pep-tide,BNP)水平、6 min步行试验(6-minute Walk Test,6MWT)及炎性因子水平.结果 治疗后观察组LVEF、BNP、6MWT等心功能指标均优于对照组,差异有统计学意义(P均<0.05).观察组白细胞介素-6、超敏C反应蛋白水平低于对照组,差异有统计学意义(t=16.614、17.966、13.423,P均<0.001).结论 沙库巴曲缬沙坦钠、琥珀酸美托洛尔联合治疗方案应用于心力衰竭患者价值显著.
Abstract
Objective To analyze the application value of the combination therapy of sacubitril valsartan sodium and metoprolol succinate in the treatment of heart failure.Methods 80 patients with chronic heart failure who were treated at Huimin County People's Hospital from January 2021 to June 2023 were selected as the research subjects,and they were randomly divided into two groups using blind selection method.The control group(40 cases)received treatment with sacubitril valsartan sodium,while the observation group(40 cases)received additional treatment with metoprolol succinate in addition to the control group.The levels of left ventricular ejection fraction(LVEF),B-type natriuretic peptide(BNP),6-minute walk test(6MWT),and inflammatory factors between two groups were compared.Results Af-ter treatment,the LVEF,BNP,and 6MWT cardiac function indicators of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).The levels of interleukin-6,hyper-sensitive C-reactive protein in observation group were lower than those in the control group,and the differences were statistically significant(t=16.614,17.966,13.423,all P<0.001).Conclusion The combination therapy of sacubitril val-sartan sodium and metoprolol succinate has significant value in the treatment of heart failure patients.
关键词
沙库巴曲缬沙坦钠/心力衰竭/琥珀酸美托洛尔/心功能/联合治疗/炎性因子Key words
Sacubitril valsartan sodium/Heart failure/Metoprolol succinate/Heart function/Combination therapy/Inflammatory factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据