Progress of Research Related to Nucleic Acid Detection Technology of Bru-cellosis
Brucellosis lacks consistency in clinical manifestations,and there are clear differences and singularities.Confirming the diagnosis of the disease as early as possible by means of laboratory tests has a positive impact on the subsequent treatment and rehabilitation of the disease.In the past,the diagnosis of brucellosis was carried out mainly by applying serologic testing methods,but such methods often lacked specificity,leading to their limited application.In contrast,nucleic acid amplification assays have been shown to have higher sensitivity and specificity in the diagno-sis of brucellosis.In this paper,the pathogenesis of brucellosis,genomics,target genes for nucleic acid detection,nucleic acid extraction methods,and nucleic acid amplification assays are discussed with a view to providing a refer-ence for nucleic acid detection techniques for brucellosis.
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