Evaluation of NLR Combined with Interleukin-6 on the Relative Risk of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Dis-ease
Objective To investigate the predictive value of neutrophil/lymphocyte ratio(NLR)combined with interleu-kin-6(IL-6)on the relative risk of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 124 patients with chronic obstructive pulmonary disease(COPD)admitted to Nanxishan Hospi-tal of Guangxi Zhuang Autonomous Region from January 2020 to December 2023 were selected as study objects and were divided into the AECOPD group(78 patients)and the COPD group(46 patients)according to whether they had an acute exacerbation or not.Independent risk factors affecting acute exacerbation of COPD patients were analyzed by multifactorial Logistic regression,and the predictive value was analyzed by receiver operating characteristic(ROC)curve.Results The NLR and IL-6 levels were significantly higher in the AECOPD group than in the COPD group,and the forced expiratory volume in the first second/forced vital capacity levels were significantly lower than in the COPD group,and the differences were statistically significant(all P<0.05).NLR and IL-6 were independent influenc-ing factors for AECOPD(both P<0.05).The area under the curve of NLR and IL-6 for predicting AECOPD was 0.948(95%CI:0.907-0.988)and 0.951(95%CI:0.918-0.985),and the area under the curve of the combination of the two for predicting AECOPD was 0.967.Conclusion The combined detection of NLR and IL-6 has an important reference value in COPD disease progression and can be used as a predictive tool for AECOPD.
万方数据
维普
